diff --git a/profiles/ghga/genome-data-hub/index.ttl b/profiles/ghga/genome-data-hub/index.ttl
new file mode 100644
index 0000000000000000000000000000000000000000..a8fb98be75392a9daf4a94f23bd465affa5b7998
--- /dev/null
+++ b/profiles/ghga/genome-data-hub/index.ttl
@@ -0,0 +1,126 @@
+@base <https://purl.org/coscine/ap/ghga/genome-data-hub/>.
+
+@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>.
+@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
+@prefix xsd: <http://www.w3.org/2001/XMLSchema#>.
+@prefix dcterms: <http://purl.org/dc/terms/>.
+@prefix sh: <http://www.w3.org/ns/shacl#>.
+@prefix vocabterms: <https://purl.org/coscine/terms/>.
+@prefix aps: <https://purl.org/coscine/ap/>.
+@prefix dbo: <http://dbpedia.org/ontology/> .
+@prefix schema: <http://schema.org/> .
+
+<https://purl.org/coscine/ap/ghga/genome-data-hub/> dcterms:created "2024-12-13"^^xsd:date;
+ dcterms:creator "Dr. Roderick Dedekind";
+ dcterms:description "Metadatenprofil zu den verschlüsselten Genomdaten im Rahmen der Cologne Genome Data Hub Unterprojekte: Deutsches Humangenom-Phaenomarchiv (GHGA) und Modellvorhaben GenomSequenzierung (MVGenomSeq, MV)"@de,
+ "Metadata profile for encrypted genomic data as part of the Cologne Genome Data Hub Subprojects: German Human Genome-Phenome Archive (GHGA) and model project Genome Sequencing (MVGenomSeq, MV)"@en;
+ dcterms:license <http://spdx.org/licenses/CC0-1.0>;
+ dcterms:subject <https://github.com/tibonto/dfgfo/205-07>;
+ dcterms:title "Cologne Genome Data Hub"@de,
+ "Cologne Genome Data Hub"@en;
+ a rdfs:Class,
+ sh:NodeShape;
+ sh:closed false;
+ sh:property [sh:datatype xsd:string ;
+ sh:minCount 1 ;
+ sh:name "Repo"@en ;
+ sh:order 1 ;
+ sh:path <https://purl.org/coscine/terms/d2b4efc1-22f7-4f9a-8e4d-b5657da68bc4/> ;
+ sh:description "Repository the file belongs to, e.g. GHGA, MV"@en ],
+ [sh:datatype xsd:string ;
+ sh:minCount 1 ;
+ sh:name "Study"@en ;
+ sh:order 2 ;
+ sh:path schema:study ;
+ sh:description "Title of the Study"@en ;
+ sh:maxCount 1 ],
+ [sh:path <http://www.ontologyrepository.com/CommonCoreOntologies/has_URI_value> ;
+ sh:datatype xsd:anyURI ;
+ sh:order 9 ;
+ sh:name "URI"@en ;
+ sh:description "Uniform Resource Identifier in S3 "@en ;
+ sh:minCount 1 ;
+ sh:maxCount 1 ],
+ [sh:path <https://saref.etsi.org/saref4inma/hasUUIDValue> ;
+ sh:datatype xsd:hexBinary ;
+ sh:order 10 ;
+ sh:name "UUID"@en ;
+ sh:description "Universally Unique Identifier for stored object"@en ;
+ sh:minCount 1 ;
+ sh:maxCount 1 ],
+ [sh:path <https://purl.org/coscine/terms/22b0c322-97cd-41a5-8a57-a4b7a0c4a288/> ;
+ sh:datatype xsd:string ;
+ sh:order 11 ;
+ sh:name "Checksum"@en ;
+ sh:minCount 1 ;
+ sh:maxCount 1 ],
+ [sh:path <https://purl.org/coscine/terms/c262f4f1-2949-411a-b7d9-64985a87b356/> ;
+ sh:datatype xsd:string ;
+ sh:order 12 ;
+ sh:name "Checksum type"@en ;
+ sh:description "Algorithm used to generate the checksum (md5, sha256)"@en ;
+ sh:minCount 1 ;
+ sh:maxCount 1 ],
+ [sh:path <https://purl.org/coscine/terms/d7a86fee-64ac-4520-9b86-b7b902425acd/> ;
+ sh:datatype xsd:string ;
+ sh:order 13 ;
+ sh:name "DAC"@en ;
+ sh:description "Data Access Committee, e.g. dac@uni-koeln.de"@en ;
+ sh:minCount 1 ],
+ [sh:path <http://www.geneontology.org/formats/oboInOwl#submitter> ;
+ sh:datatype xsd:string ;
+ sh:order 3 ;
+ sh:description "Name of the institution of origin"@en, "Name der Herkunftsinstitution "@de ;
+ sh:name "Submitter"@en ;
+ sh:minCount 1 ;
+ sh:maxCount 1 ],
+ [sh:datatype xsd:date ;
+ sh:minCount 1 ;
+ sh:name "Submission Date"@en ;
+ sh:order 4 ;
+ sh:path dcterms:date ;
+ sh:maxCount 1 ],
+ [sh:datatype xsd:string ;
+ sh:minCount 1 ;
+ sh:name "Application"@en ;
+ sh:order 5 ;
+ sh:path <https://purl.org/coscine/terms/44966765-5228-4da5-b72f-fdcdc2334dff/> ;
+ sh:description "Sequencing Application used, e.g. WGS"@en ;
+ sh:maxCount 1 ],
+ [sh:datatype xsd:string ;
+ sh:minCount 1 ;
+ sh:name "Individual ID"@en ;
+ sh:order 6 ;
+ sh:path <https://purl.org/coscine/terms/b9816141-3f4b-4aaa-a607-0140920f1ced/> ;
+ sh:description "ID of the patient"@en ;
+ sh:maxCount 1 ],
+ [sh:datatype xsd:string ;
+ sh:minCount 1 ;
+ sh:name "Filename"@en ;
+ sh:order 7 ;
+ sh:path dbo:filename ;
+ sh:description "Original Filename as submitted"@en ;
+ sh:maxCount 1 ],
+ [sh:datatype xsd:string ;
+ sh:minCount 1 ;
+ sh:name "File Type"@en ;
+ sh:order 8 ;
+ sh:path <https://purl.org/coscine/terms/bc325b84-46b8-40fd-8dde-88e8a2eee44c/> ;
+ sh:description "File format, e.g. FASTQ, BAM, VCF"@en ;
+ sh:maxCount 1 ],
+ [sh:path <https://purl.org/coscine/terms/d1158ab0-dc7c-4c8c-9a98-d5cbef9e6ded/> ;
+ sh:order 14 ;
+ sh:name "Status GHGA"@de ;
+ sh:name "Status GHGA"@en ;
+ sh:description "Availability status of the file within GHGA"@en ;
+ sh:minCount 1 ;
+ sh:maxCount 1 ;
+ sh:in ("active" "inactive" "retracted" "locked" "deleted")],
+ [sh:path <https://purl.org/coscine/terms/c23730f6-d5a7-4768-a59c-afc8fa8ce330/> ;
+ sh:order 15 ;
+ sh:name "Status MV"@de ;
+ sh:name "Status MV"@en ;
+ sh:description "Availability status of the file within MVGenomSeq"@en ;
+ sh:minCount 1 ;
+ sh:maxCount 1 ;
+ sh:in ("active" "inactive" "retracted" "locked" "deleted")].